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Titel:

Regulation of autophagy by ATF4 in response to severe hypoxia.

Dokumenttyp:
Journal Article
Autor(en):
Rzymski, T; Milani, M; Pike, L; Buffa, F; Mellor, HR; Winchester, L; Pires, I; Hammond, E; Ragoussis, I; Harris, AL
Abstract:
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small interfering RNA (siRNA) and microarray analysis to provide the first whole-genome analysis of genes regulated by ATF4 in cancer cells in response to severe and prolonged hypoxic stress....     »
Zeitschriftentitel:
Oncogene
Jahr:
2010
Band / Volume:
29
Heft / Issue:
31
Seitenangaben Beitrag:
4424-35
Sprache:
eng
Volltext / DOI:
doi:10.1038/onc.2010.191
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20514020
Print-ISSN:
0950-9232
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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