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Title:

A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1alpha (HIF1A) gene in elite endurance athletes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Döring, F; Onur, S; Fischer, A; Boulay, MR; Pérusse, L; Rankinen, T; Rauramaa, R; Wolfarth, B; Bouchard, C
Abstract:
Hypoxia-inducible factor-1alpha (HIF1A) is a transcription factor regulating several genes in response to hypoxic stimuli. HIF1A target genes code for proteins involved in oxygen transport, glycolytic enzymes, and glucose transporters. We investigated whether single-nucleotide polymorphisms and haplotypes in the HIF1A gene are associated with endurance performance in the Genathlete cohort, which includes 316 Caucasian male elite endurance athletes (EEA) with a maximal oxygen uptake of 79.0+/-3.5...     »
Journal title abbreviation:
J Appl Physiol
Year:
2010
Journal volume:
108
Journal issue:
6
Pages contribution:
1497-500
Language:
eng
Fulltext / DOI:
doi:10.1152/japplphysiol.01165.2009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20299614
Print-ISSN:
8750-7587
TUM Institution:
Poliklinik für Präventive und Rehabilitative Sportmedizin
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