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Title:

Rationale and design of the 'aldosterone receptor blockade in diastolic heart failure' trial: a double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in pa

Document type:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Author(s):
Edelmann, F; Schmidt, AG; Gelbrich, G; Binder, L; Herrmann-Lingen, C; Halle, M; Hasenfuss, G; Wachter, R; Pieske, B
Abstract:
Increasing evidence suggests that enhanced aldosterone signalling plays a key role in the onset and progression of diastolic heart failure (DHF). Aldo-DHF will test the hypothesis that aldosterone receptor blockade by spironolactone will improve exercise capacity and diastolic function in patients with DHF.Aldo-DHF is a randomized, placebo-controlled, double-blinded, two-armed, multicentre, parallel group study. Four hundred and twenty patients with DHF will be randomly assigned to receive spiro...     »
Journal title abbreviation:
Eur J Heart Fail
Year:
2010
Journal volume:
12
Journal issue:
8
Pages contribution:
874-82
Language:
eng
Fulltext / DOI:
doi:10.1093/eurjhf/hfq087
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20538867
Print-ISSN:
1388-9842
TUM Institution:
Poliklinik für Präventive und Rehabilitative Sportmedizin
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