The amino acid sequence isoAsp-Gly-Arg was recognized as a new binding motif involved in integrin interactions. To explore the structure activity relationship of this sequence head-to-tail cyclized peptides containing this new motif were synthesized. Binding affinities for the closely related integrins αvβ3 and α5β1 were investigated. As a result, an active pentapeptide was found, which after optimization led to the identification of several highly active α5β1 ligands with highly selective towards αvβ3.     «

The amino acid sequence isoAsp-Gly-Arg was recognized as a new binding motif involved in integrin interactions. To explore the structure activity relationship of this sequence head-to-tail cyclized peptides containing this new motif were synthesized. Binding affinities for the closely related integrins αvβ3 and α5β1 were investigated. As a result, an active pentapeptide was found, which after optimization led to the identification of several highly active α5β1 ligands with highly selective towar...     »