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Titel:

New opportunities in drug design of metalloproteinase inhibitors: combination between structure-function experimental approaches and systems biology.

Dokumenttyp:
Journal Article
Autor(en):
Sela-Passwell, N; Trahtenherts, A; Kruger, A; Sagi, I
Abstract:
Introduction: MMPs (matrix metalloproteinases) and ADAMs (a disintegrin and metalloproteinases) are endopeptidases central to the degradation and remodeling of the extracellular matrix. These proteases also exhibit regulatory activity in cell signaling pathways and thus tissue homeostasis under normal conditions and in many diseases. Consequently, individual members of the MMP and ADAM protein families were identified as important therapeutic targets. However, designing effective inhibitors in v...     »
Zeitschriftentitel:
Expert Opin Drug Discov
Jahr:
2011
Band / Volume:
6
Heft / Issue:
5
Seitenangaben Beitrag:
527-42
Sprache:
eng
Volltext / DOI:
doi:10.1517/17460441.2011.560936
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22646077
Print-ISSN:
1746-0441
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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