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Title:

YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Holzmüller, R; Mantwill, K; Haczek, C; Rognoni, E; Anton, M; Kasajima, A; Weichert, W; Treue, D; Lage, H; Schuster, T; Schlegel, J; Gansbacher, B; Holm, PS
Abstract:
The human Y-box binding protein 1 (YB-1) is known to be a promising target for cancer therapy. We have demonstrated that YB-1 plays an important role in the adenoviral life cycle by regulating the adenoviral E2-gene expression. Thus, we studied the oncolytic effect of the recombinant adenovirus Ad-Delo3-RGD, in which the transactivation domain CR3 of the E1A protein is ablated to enable viral replication only in YB-1 positive cancer cells. In vitro Southern Blot analysis and cytopathic effect as...     »
Journal title abbreviation:
Int J Cancer
Year:
2011
Journal volume:
129
Journal issue:
5
Pages contribution:
1265-76
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.25783
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21710499
Print-ISSN:
0020-7136
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Medizinische Statistik und Epidemiologie
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