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Title:

Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine.

Document type:
journal article
Author(s):
Ari, F; Napieralski, R; Ulukaya, E; Dere, E; Colling, C; Honert, K; Krüger, A; Kiechle, M; Schmitt, M
Abstract:
Epigenetic drugs are promising add-ons to cancer treatment; still, adverse effects concerning tumour promotion have been reported occasionally. In this in vitro study, we investigated the effect of combination treatment of decitabine with anthracycline-based chemotherapy [5-fluorouracil plus epirubicine plus cyclophosphamide (FEC)] on viability and metastatic activity of breast cancer cell lines, MDA-MB-231 (estrogen receptor-negative) and MCF-7 (estrogen receptor-positive). The effect of decit...     »
Journal title abbreviation:
Cell Biochem Funct
Year:
2011
Journal volume:
29
Journal issue:
8
Pages contribution:
651-9
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21887697
Print-ISSN:
0263-6484
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung
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