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Title:

A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kolk, A; Haczek, C; Koch, C; Vogt, S; Kullmer, M; Pautke, C; Deppe, H; Plank, C
Abstract:
Bioactive implants are promising tools in regenerative medicine. Here we describe a versatile procedure for preparing a gene-activated matrix on titanium. Lyophilized copolymer-protected gene vectors (COPROGs) suspended in poly(d,l-lactide) (PDLLA) solutions in ethyl acetate were used to varnish solid surfaces. The gene-activated PDLLA surfaces were first established on polypropylene 96-well plates. Vector release from these surfaces in aqueous buffer, cell viability and gene transfer efficiency...     »
Journal title abbreviation:
Biomaterials
Year:
2011
Journal volume:
32
Journal issue:
28
Pages contribution:
6850-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biomaterials.2011.05.071
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21741701
Print-ISSN:
0142-9612
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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