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Titel:

Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1?.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schelter, F; Halbgewachs, B; Bäumler, P; Neu, C; Gorlach, A; Schrötzlmair, F; Kruger, A
Abstract:
The "protease web", representing the network of proteases, their inhibitors, and effector molecules, arises as a pivotal determinant of tissue homeostasis. Imbalances of this network, for instance caused by elevated host levels of tissue inhibitor of metalloproteinases-1 (TIMP-1), have been shown to increase the susceptibility of target organs to scattered metastasis by inducing the hepatocyte growth factor (HGF) pathway. Increased expression of the hypoxia-inducible factor-1?-subunit (HIF-1?) i...     »
Zeitschriftentitel:
Clin Exp Metastasis
Jahr:
2011
Band / Volume:
28
Heft / Issue:
2
Seitenangaben Beitrag:
91-9
Sprache:
eng
Volltext / DOI:
doi:10.1007/s10585-010-9360-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21053058
Print-ISSN:
0262-0898
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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