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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Boettler, Ute; Sommerfeld, Katharina; Volz, Nadine; Pahlke, Gudrun; Teller, Nicole; Somoza, Veronika; Lang, Roman; Hofmann, Thomas; Marko, Doris 
Titel:
Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression 
Abstract:
Oxidative cellular stress initiates Nrf2 translocation into the nucleus, thus inducing antioxidant response element (ARE)-mediated expression of Phase II enzymes involved in detoxification and antioxidant defence. We investigated whether coffee extracts (CEs) of different proveniences and selected constituents have an impact on the Nrf2/ARE pathway in human colon carcinoma cells (HT29). Assessed as increased nuclear Nrf2 protein, Nrf2 nuclear translocation was modulated by different CEs as obser...    »
 
Zeitschriftentitel:
The Journal of Nutritional Biochemistry 
Jahr:
2011 
Band / Volume:
22 
Heft / Issue:
Seitenangaben Beitrag:
426--440 
Print-ISSN:
0955-2863