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- Document type:
- Journal Article
- Author(s):
- Schnapperelle, I.; Breitenlechner, S.; Bach, T.
- Title:
- Regioselective Oxidative Coupling Reactions of 3-Substituted Thiophenes with Arylboronic Acids
- Abstract:
- Under optimized conditions, 3-substituted thiophenes (EWG = COOEt, PO(OEt)2) undergo a facile and regioselective oxidative coupling reaction at carbon atom C4. The reactions were performed with various aryl boronic acids as nucleophiles in the presence of silver oxide (2.0 equiv), cesium trifluoroacetate (tfa) (1.0 equiv), benzoquinone (BQ) (0.5 equiv), and catalytic amounts of Pd(tfa)2 (10 mol %) employing trifluoroacetic acid (TFA) as the solvent.
- Congress title:
- ISI Document Delivery No.: 788YC Times Cited: 8 Cited Reference Count: 32 Schnapperelle, Ingo Breitenlechner, Stefan Bach, Thorsten TUM Graduate School I.S. gratefully acknowledges support by the TUM Graduate School. 8 Amer chemical soc Washington
- Journal title:
- Organic Letters
- Year:
- 2011
- Journal volume:
- 13
- Journal issue:
- 14
- Pages contribution:
- 3640-3643
- Fulltext / DOI:
- doi:10.1021/ol201292v
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