Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms.

Oka, Naomi; Kasajima, Atsuko; Konukiewitz, Björn; Sakurada, Akira; Okada, Yoshinori; Kameya, Toru; Weichert, Wilko; Ishikawa, Yuichi; Suzuki, Hiroyoshi; Sasano, Hironobu; Klöppel, Günter

doi:10.1159/000502776

User: Guest

journal article

Title:: Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms.
Document type:: Journal Article
Author(s):: Oka, Naomi; Kasajima, Atsuko; Konukiewitz, Björn; Sakurada, Akira; Okada, Yoshinori; Kameya, Toru; Weichert, Wilko; Ishikawa, Yuichi; Suzuki, Hiroyoshi; Sasano, Hironobu; Klöppel, Günter
Abstract:: The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accuracy and prognostic impact. Two BP-NEN cohorts from Japan and Germany, 393 tumors (88% surgically resected), were reviewed and the clinicopathological data of the resected tumors (n = 301) correlated to patients' disease-free survival (DFS). The DiS-NEN-WHO 2019 stratified the 350 tumors into 91 (26%) neuroendocrine tumors (NET) G1, 52 (15%) NET G2, 15 (4%) NET G3, and 192 (55%) neuroendocrine carcinomas (NEC). NECs, but not NETs, were immunohistochemically characterized by abnormal p53 (100%) and retinoblastoma 1 (83%) expression. The Ki67 index, which was on average 4 times higher than mitotic count (p < 0.0001), was prognostically more accurate than the mitotic count. NET G3 patients had a worse outcome than NET G1 (p < 0.01) and NET G2 patients (p = 0.02), respectively. No prognostic difference was detected between NET G3 and NEC patients after 5 year DFS. It is concluded that stratifying BP-NEN patients according to the DiS-NEN-WHO 2019 classification results in 3 prognostically well-defined NET groups, if grading is solely based on Ki67 index. Mitotic count alone may underestimate malignant potential of NETs.
Journal title abbreviation:: Neuroendocrinology
Year:: 2020
Journal volume:: 110
Journal issue:: 5
Pages contribution:: 393-403
Fulltext / DOI:: doi:10.1159/000502776
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/31422400
Print-ISSN:: 0028-3835
TUM Institution:: Institut für Allgemeine Pathologie und Pathologische Anatomie
BibTeX

Occurrences:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2020

mediaTUM Gesamtbestand Hochschulbibliographie 2020 Fakultäten Medizin Institut für Allgemeine Pathologie und Pathologische Anatomie