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Titel:

An optimized purification process for porcine gastric mucin with preservation of its native functional properties

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Schömig, Veronika J.; Käsdorf, Benjamin T.; Scholz, Christoph; Bidmon, Konstantinia; Lieleg, Oliver; Berensmeier, Sonja
Abstract:
Purified gastric mucins are currently used for a wide range of applications e.g. as a model system for native mucus, as lubricants or antiviral/antibacterial supplements. However, commercially available porcine gastric mucins (PGM) do not exhibit gel-forming properties and show only greatly reduced anti-viral/anti-bacterial activity. Thus, we established a robust purification process for PGM, maintaining its desired properties such as lubricity, gel formation and the selective binding of molecul...     »
Stichworte:
SOL-GEL TRANSITION; MUCUS GLYCOPROTEINS; CONCENTRATION POLARIZATION; HYDROPHOBIC SURFACES; STRUCTURAL-ANALYSIS; POLYMERIC STRUCTURE; PURIFY MUCINS; PH; ADSORPTION; FLUX
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
RSC Adv.
Jahr:
2016
Jahr / Monat:
2016-04
Heft / Issue:
50
Seitenangaben Beitrag:
44932-44943
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1039/c6ra07424c
WWW:
http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra07424c#!divAbstract
Verlag / Institution:
Royal Society of Chemistry (RSC)
Publikationsdatum:
01.01.2016
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