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- Original title:
- Genexpressionsuntersuchungen von Genen der homologen Rekombinationsreparatur beim Ovarialkarzinom
- Translated title:
- mRNA analysis of genes implicated in homologous recombination deficiency in ovarian cancer
- Author:
- Brunet, Theresa
- Year:
- 2020
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Kiechle, Marion B. (Prof. Dr.)
- Referee:
- Kiechle, Marion B. (Prof. Dr.); Keller, Gisela (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- Ovarialkarzinom, BRCAness, BRCA1, BRIP1, RAD51C, PARP-Inhibitoren, homologes Rekombinationsdefizit
- Translated keywords:
- ovarian cancer, BRCAness, BRCA1, BRIP1, RAD51C, PARP inhibitors, homologous recombination deficiency
- TUM classification:
- MED 560d; MED 320d
- Abstract:
- Ovarialkarzinomproben von 49 Patientinnen wurden durch den MLPA BRCA1ness Test in ein BRCA1-ähnliches bzw. nicht-BRCA1-ähnliches Tumorprofil klassifiziert und mRNA-Expressionswerte von sieben Genen (ATM, BRIP1, BRCA1, BRCA2, CHEK2, RAD51C, RAD51D), die für Proteine der homologen Rekombinationsreparatur (HR) kodieren, wurden bestimmt. Niedrige mRNA-Expressionswerte von BRIP1, BRCA1 und RAD51C waren mit einem besseren Gesamtüberleben assoziiert. In der Cox-Regression waren die BRIP1 mRNA-Expressio... »
- Translated abstract:
- Ovarian cancer tissues of 49 patients were classified in BRCA1-like or non-BRCA1-like by the MLPA BRCA1ness test and mRNA levels of seven genes (ATM, BRIP1, BRCA1, BRCA2, CHEK2, RAD51C, RAD51D) involved in homologous recombination (HR) were determined. Low mRNA levels of BRIP1, BRCA1 and RAD51C were associated with favorable overall survival. Cox-regression showed a prognostic significance of BRIP1 mRNA expression and a prognostic significance of the estimated tumor profile by MLPA.
- WWW:
- https://mediatum.ub.tum.de/?id=1535975
- Date of submission:
- 05.02.2020
- Oral examination:
- 07.09.2020
- File size:
- 5707045 bytes
- Pages:
- 105
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20200907-1535975-1-9
- Last change:
- 16.10.2020
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