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- Original title:
- The role of transient fetal hypoxia in the development of pulmonary hypertension dependent on p22phox
- Translated title:
- Die Rolle transienter fetaler Hypoxie in der Entwicklung von pulmonaler Hypertension abhängig von p22phox
- Author:
- Haufe, Katharina Patricia
- Year:
- 2024
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Institution:
- Professur für Experimentelle und Molekulare Kinderkardiologie (Dr. Görlach)
- Advisor:
- Görlach, Agnes (Prof. Dr.)
- Referee:
- Görlach, Agnes (Prof. Dr.); Steiger, Katja (Priv.-Doz. Dr.)
- Language:
- en
- Subject group:
- MED Medizin
- Keywords:
- p22phox; pulmonary hypertension; fetal hypoxia
- Translated keywords:
- p22phox; pulmonale Hypertension; fetale Hypoxie
- TUM classification:
- MED 410; MED 580
- Abstract:
- This study examines the effect of transient fetal hypoxia on the development of pulmonary hypertension (PH) as an adult in nmf333 mice, which are deficient in p22phox. P22phox activates NOX 1-4 (NADPH oxidases), which are producing reactive oxygen species (ROS). Control group showed signs of PH as an adult, while nmf333 mice were protected against this effect. P22phox deficiency also protects against oxidative DNA damage and ROS production in vivo and in vitro.
- Translated abstract:
- Diese Arbeit untersucht den Effekt von transienter fetaler Hypoxie auf die Entwicklung von pulmonaler Hypertension (PH) in adulten nmf333 Mäusen, die einen Mangel an p22phox haben. P22phox aktiviert NOX 1-4 (NADPH Oxidasen), welche reaktive Sauerstoffspezies (ROS) produzieren. Die Kontrollgruppe zeigte Anzeichen für PH, während die nmf333 Mäuse gegen diesen Effekt geschützt waren. Ein p22phox Mangel schützte ebenfalls gegen oxidativen DNA-Schaden sowie ROS-Produktion in vivo und in vitro.
- WWW:
- https://mediatum.ub.tum.de/?id=1749493
- Date of submission:
- 07.08.2024
- Oral examination:
- 17.12.2024
- File size:
- 2865655 bytes
- Pages:
- 117
- Urn (citeable URL):
- https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20241217-1749493-0-4
- Last change:
- 31.01.2025
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