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- Original title:
- Vergleich der osteogenen Differenzierung primärer Osteoblasten sowie junger und alter Ad-MSCs in 2D und 3D Kulturen
- Translated title:
- Comparison of the osteogenic differentiation of primary osteoblasts as well as young and old Ad-MSCs in 2D and 3D cultures
- Author:
- Schuseil, Tim
- Year:
- 2021
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- van Griensven, Martijn (Prof. Dr.)
- Referee:
- van Griensven, Martijn (Prof. Dr.); von Eisenhart-Rothe, Rüdiger (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- TUM classification:
- MED 530d
- Abstract:
- Das Ziel dieser Arbeit war es Ad-MSCs (adipose-derived mesenchymal stem cells) als mögliche Spenderquelle osteogener Zellen zu kultivieren und ihre osteogene Differenzierbarkeit im Hinblick auf das unterschiedliche Alter und verschiedene Differenzierungsbedingungen zu quantifizieren. Dabei konnten eine Verbesserung der osteogenen Zelldifferenzierung durch Einsatz von 3D Strukturen sowie ein gutes osteogenes Differenzierungspotential besonders alter Ad-MSCs nachgewiesen werden.
- Translated abstract:
- The aim of this project was to culture Ad-MSCs (adipose-derived mesenchymal stem cells) as a potential source for osteogenic cells and to quantify their osteogenic differentiability in view of differing patient age and differing culture conditions. Based on the results yielded in this work, we can conclude that the osteogenic cell differentiation is improved by the application of 3D structures and also a good osteogenic differentiation potential particularly of old Ad-MSCs.
- WWW:
- https://mediatum.ub.tum.de/?id=1534038
- Date of submission:
- 13.02.2020
- Oral examination:
- 26.01.2021
- File size:
- 4723830 bytes
- Pages:
- 147
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20210126-1534038-1-0
- Last change:
- 17.05.2021
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