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- Original title:
- Tumor shrinkage assessed by volumetric MRI in long-term follow-up after fractionated stereotactic radiotherapy of nonfunctioning pituitary adenoma and fractionated stereotactic radiotherapy in the treatment of pituitary adenomas
- Translated title:
- Tumorremission bewertet mittels volumetrischer MRT im Langzeitverlauf nach fraktionierter stereotaktischer Strahlentherapie von nicht-funktionellen Hypophysenadenomen und Fraktionierte stereotaktische Strahlentherapie in der Behandlung von Hypophysenadenomen
- Author:
- Poullos, Nektarios
- Year:
- 2024
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Advisor:
- Molls, Michael (Prof. Dr.)
- Referee:
- Molls, Michael (Prof. Dr.); Combs, Stephanie E. (Prof. Dr.)
- Language:
- en
- Subject group:
- MED Medizin
- Keywords:
- pituitary adenomas ; stereotactic radiotherapy ; volumetric evaluation
- Translated keywords:
- hypophysenadenomas ; stereotaktisch fraktionierter Strahlentherapie (SFS) ; MRT Volumetrie
- TUM classification:
- MED 000
- Abstract:
- One aim of this study is to quantitatively analyze tumor shrinkage after fractionated stereotactic radiotherapy (FSRT) of pituitary adenomas by 3-D MRI. Exact evaluation of radiological tumor response to stereotactic radiotherapy seems to us of major importance in the subgroup of non-functioning pituitary adenomas N9FPAs), as compared to hormone secreting pituitary adenomas, where hormone levels are the main criteria to evaluate response to therapy, NFPAs lack this criteria for clinical evaluation of tumor control. The other aim of this study is to evaluate the role of FSRT (fractionated stereotactic radiotherapy) in the management of non-functioning and functioning pituitary adenomas in the postoperative setting, with respect to tumor control and side effects of radiotherapy.In conclusion, we think that volumetric evaluation of tumor size after radiotherapy of pituitary adenomas using 3D T1Gd-MRI is a highly precise method to measure tumor regression. In all pituitary adenomas a size reduction was detected, representing 100% radiological response.We report 26%, 47% and 62% reduction in tumor volume of NFPAs at < 36, 36 – 72 and > 72 months after radiotherapy
- Translated abstract:
- Etwa 90% der strahlentherapeutisch behandelten Hypophysenadenome zeigen ein Therapieansprechen (Remission oder stable disease). Es gibt nur wenige Daten über den Verlauf der Größenregredienz nach erfolgreicher stereotaktisch fraktionierter Strahlentherapie (SFS). Ziel dieser Untersuchung war die volumetrische Erfassung des Remissionsverhaltens von Hypophysenadenomen nach stereotaktischer Strahlentherapie. Methodisch basiert die vorliegende Arbeit auf der Volumetrie, die das jeweils aktuell... »
- WWW:
- https://mediatum.ub.tum.de/?id=1506647
- Date of submission:
- 25.05.2023
- Oral examination:
- 18.07.2024
- File size:
- 1014526 bytes
- Pages:
- 43
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20240718-1506647-1-0
- Last change:
- 20.09.2024
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