This work evaluates migration in breast cancer cell lines using an improved gap closure assay. Four cell lines (T47D, MDA-MB 361, MCF-7 and SkBr3) were irradiated with doses of 0, 2, 4 and 8 Gy. Migration, apoptosis and cell viability was analyzed. The cell line SkBr3 showed a statistically significant increase in migration in the 4 Gy and 8 Gy groups compared to sham irradiation. MCF-7 cells showed no statistically significant effect, but a tendency was observed. Significant changes in apoptosis or cell viability could not be detected (other than the expected results in the 8 Gy subgroup).
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This work evaluates migration in breast cancer cell lines using an improved gap closure assay. Four cell lines (T47D, MDA-MB 361, MCF-7 and SkBr3) were irradiated with doses of 0, 2, 4 and 8 Gy. Migration, apoptosis and cell viability was analyzed. The cell line SkBr3 showed a statistically significant increase in migration in the 4 Gy and 8 Gy groups compared to sham irradiation. MCF-7 cells showed no statistically significant effect, but a tendency was observed. Significant changes in apoptosi...
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