Germinal centers (GCs) are origin of most of B cell neoplasms. Somatic mutations and chromosomal lesions orchestrate the transformation of GCB cells. High throughput sequencing studies revealed the multi-hit nature of them and identified many recurrent genetic alterations. However, the challenge remains to characterize the (mal) functions and molecular networks of these alterations. In this regard here I describe a novel in vivo model that allows for functional interrogations to identify critical players of GCB cells and GC derived lymphomas.      «

Germinal centers (GCs) are origin of most of B cell neoplasms. Somatic mutations and chromosomal lesions orchestrate the transformation of GCB cells. High throughput sequencing studies revealed the multi-hit nature of them and identified many recurrent genetic alterations. However, the challenge remains to characterize the (mal) functions and molecular networks of these alterations. In this regard here I describe a novel in vivo model that allows for functional interrogations to identify critica...     »