Login
- Original title:
- Der Effekt einer oralen Applikation Pektin-Chitosan-beschichteter Ac2-26-Nanopartikel auf die Heilung intestinaler Anastomosen unter experimenteller Kolitis im Mausmodell
- Translated title:
- The effect of oral application of pectin-chitosan-coated Ac2-26-nanoparticles on the healing of intestinal anastomoses under experimental colitis in a murine model
- Author:
- Walter, Robert Leon
- Year:
- 2025
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Institution:
- Klinik und Poliklinik für Chirurgie (Prof. Friess)
- Advisor:
- Neumann, Philipp-Alexander (Priv.-Doz. Dr.)
- Referee:
- Neumann, Philipp-Alexander (Priv.-Doz. Dr.); Rad, Radu Roland (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- Anastomosenheilung; Colitis ulcerosa; Kolitis; Mausmodell; Mikrochirurgie; Nanopartikel; Ac2-26; ANXA1; Anastomose
- Translated keywords:
- anastomotic healing; nanoparticles; colitis; ulcerative colitis; murine model; microsurgery; surgery; anastomosis; Ac2-26; ANXA1
- TUM classification:
- MED 510
- Abstract:
- Die Therapie entzündlicher Darmerkrankungen umfasst häufig komplikationsbehaftete Anastomosenchirurgie. In einem Mausmodell wird der perioperative Einfluss des entzündungsregulierenden Peptids Ac2-26 auf Darmanatomosen im entzündeten Gewebe untersucht. Die orale Applikation dieses Peptids anhand vom Nanopartikeln verbessert die Heilung signifikant. Dies wird durch histologische, klinische und funktionelle Evaluationsmethoden gezeigt.
- Translated abstract:
- The treatment of inflammatory bowel diseases often involves anastomosis surgery, which is associated with complications. The perioperative influence of the inflammation-regulating peptide Ac2-26 on intestinal anatomoses in the inflamed tissue is being investigated in a mouse model. The oral application of this peptide using nanoparticles significantly improves healing. This is demonstrated by histological, clinical and functional evaluation methods.
- WWW:
- https://mediatum.ub.tum.de/?id=1738354
- Date of submission:
- 19.04.2024
- Oral examination:
- 24.02.2025
- File size:
- 1657685 bytes
- Pages:
- 95
- Urn (citeable URL):
- https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20250224-1738354-0-4
- Last change:
- 24.03.2025
BibTeX