Login
- Original title:
- Effects of Ccn2 loss during hematopoietic stress
- Translated title:
- Die Auswirkung des Ccn2 Verlustes während hämatopoetischem Stress
- Author:
- Romero Marquez, Sandra
- Year:
- 2023
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Advisor:
- Oostendorp, Robert (Prof. Dr.)
- Referee:
- Oostendorp, Robert (Prof. Dr.); Schnieke, Angelika (Prof., Ph.D.)
- Language:
- en
- Subject group:
- BIO Biowissenschaften
- TUM classification:
- BIO 000
- Abstract:
- Preservation of hematopoietic stem cells (HSCs) is the main function of the bone marrow microenvironment. Therefore, we investigated the matricellular protein Cellular Communication Network factor 2 (Ccn2). Although, Ccn2 is dispensable at steady state, during irradiation stress osteoblastic Ccn2 seems to be necessary for the secretion of pro-inflammatory cytokines of the niche. Moreover, it is essential for a correct DNA repair mechanism during stress induced HSC proliferation.
- Translated abstract:
- Die Erhaltung hämatopoetischer Stammzellen (HSZs) ist die Hauptfunktion der Mikroumgebung des Knochenmarks. Wir untersuchten das matrizelluläre Protein “Cellular Communication Network Factor 2” (Ccn2). Obwohl Ccn2 in “Steady State” entbehrlich ist, scheint osteoblastisches Ccn2 bei Bestrahlungsstress für die Sekretion proinflammatorischer Zytokine der Nische notwendig zu sein. Zudem ist es für einen korrekten DNA-Reparaturmechanismus während der stressinduzierten HSZ-Proliferation unerlässlich.
- WWW:
- https://mediatum.ub.tum.de/?id=1691157
- Date of submission:
- 17.11.2022
- Oral examination:
- 24.07.2023
- File size:
- 12005610 bytes
- Pages:
- 227
- Urn (citeable URL):
- https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20230724-1691157-1-4
- Last change:
- 24.01.2025
BibTeX