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Title:

In Vitro Cartilage Regeneration with a Three-Dimensional Polyglycolic Acid (PGA) Implant in a Bovine Cartilage Punch Model.

Document type:
Journal Article
Author(s):
Horbert, Victoria; Xin, Long; Föhr, Peter; Huber, René; Burgkart, Rainer H; Kinne, Raimund W
Abstract:
Resorbable polyglycolic acid (PGA) chondrocyte grafts are clinically established for human articular cartilage defects. Long-term implant performance was addressed in a standardized in vitro model. PGA implants (+/- bovine chondrocytes) were placed inside cartilage rings punched out of bovine femoral trochleas (outer Ø 6 mm; inner defect Ø 2 mm) and cultured for 84 days (12 weeks). Cartilage/PGA hybrids were subsequently analyzed by histology (hematoxylin/eosin; safranin O), immunohistochemist...     »
Journal title abbreviation:
Int J Mol Sci
Year:
2021
Journal volume:
22
Journal issue:
21
Fulltext / DOI:
doi:10.3390/ijms222111769
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34769199
Print-ISSN:
1422-0067
TUM Institution:
Klinik und Poliklinik für Orthopädie und Sportorthopädie
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