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Titel:

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.

Dokumenttyp:
Article; Early Access; Journal Article
Autor(en):
Zheng, Yan; Huang, Tao; Wang, Tiange; Mei, Zhendong; Sun, Zhonghan; Zhang, Tao; Ellervik, Christina; Chai, Jin-Fang; Sim, Xueling; van Dam, Rob M; Tai, E-Shyong; Koh, Woon-Puay; Dorajoo, Rajkumar; Saw, Seang-Mei; Sabanayagam, Charumathi; Wong, Tien Yin; Gupta, Preeti; Rossing, Peter; Ahluwalia, Tarunveer S; Vinding, Rebecca K; Bisgaard, Hans; Bønnelykke, Klaus; Wang, Yujie; Graff, Mariaelisa; Voortman, Trudy; van Rooij, Frank J A; Hofman, Albert; van Heemst, Diana; Noordam, Raymond; Estampador,...     »
Abstract:
Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide a...     »
Zeitschriftentitel:
Eur J Epidemiol
Jahr:
2020
Band / Volume:
35
Heft / Issue:
7
Seitenangaben Beitrag:
685-697
Volltext / DOI:
doi:10.1007/s10654-020-00638-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32383070
Print-ISSN:
0393-2990
TUM Einrichtung:
611; 656; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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