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Title:

Tumor-associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance.

Document type:
Review; Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Plesca, Ioana; Müller, Luise; Böttcher, Jan P; Medyouf, Hind; Wehner, Rebekka; Schmitz, Marc
Abstract:
DCs play a pivotal role in orchestrating innate and adaptive antitumor immunity. Activated DCs can produce large amounts of various proinflammatory cytokines, initiate T-cell responses, and exhibit direct cytotoxicity against tumor cells. They also efficiently enhance the antitumoral properties of NK cells and T lymphocytes. Based on these capabilities, immunogenic DCs promote tumor elimination and are associated with improved survival of patients. Furthermore, they can essentially contribute to...     »
Journal title abbreviation:
Eur J Immunol
Year:
2022
Journal volume:
52
Journal issue:
11
Pages contribution:
1750-1758
Fulltext / DOI:
doi:10.1002/eji.202149487
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35106759
Print-ISSN:
0014-2980
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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