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Title:

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zenke, Simon; Palm, Margriet M; Braun, Julia; Gavrilov, Alina; Meiser, Philippa; Böttcher, Jan P; Beyersdorf, Niklas; Ehl, Stephan; Gerard, Audrey; Lämmermann, Tim; Schumacher, Ton N; Beltman, Joost B; Rohr, Jan C
Abstract:
T cell responses upon infection display a remarkably reproducible pattern of expansion, contraction, and memory formation. If the robustness of this pattern builds entirely on signals derived from other cell types or if activated T cells themselves contribute to the orchestration of these population dynamics-akin to bacterial quorum regulation-is unclear. Here, we examined this question using time-lapse microscopy, genetic perturbation, bioinformatic predictions, and mathematical modeling. We fo...     »
Journal title abbreviation:
Immunity
Year:
2020
Journal volume:
52
Journal issue:
2
Pages contribution:
313-327.e7
Fulltext / DOI:
doi:10.1016/j.immuni.2020.01.018
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32049052
Print-ISSN:
1074-7613
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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