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Titel:

FGF2 Affects Parkinson's Disease-Associated Molecular Networks Through Exosomal Rab8b/Rab31.

Dokumenttyp:
Article; Journal Article
Autor(en):
Kumar, Rohit; Donakonda, Sainitin; Müller, Stephan A; Bötzel, Kai; Höglinger, Günter U; Koeglsperger, Thomas
Abstract:
Ras-associated binding (Rab) proteins are small GTPases that regulate the trafficking of membrane components during endocytosis and exocytosis including the release of extracellular vesicles (EVs). Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorder in the elderly population, where pathological proteins such as alpha-synuclein (α-Syn) are transmitted in EVs from one neuron to another neuron and ultimately across brain regions, thereby facilitating the spreading of pa...     »
Zeitschriftentitel:
Front Genet
Jahr:
2020
Band / Volume:
11
Volltext / DOI:
doi:10.3389/fgene.2020.572058
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33101391
Print-ISSN:
1664-8021
TUM Einrichtung:
617; Roman Herzog Comprehensive Cancer Center
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