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Titel:

Synthetic Mucin Gels with Self‐Healing Properties Augment Lubricity and Inhibit HIV‐1 and HSV‐2 Transmission

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Kretschmer, Martin; Ceña‐Diez, Rafael; Butnarasu, Cosmin; Silveira, Valentin; Dobryden, Illia; Visentin, Sonja; Berglund, Per; Sönnerborg, Anders; Lieleg, Oliver; Crouzier, Thomas; Yan, Hongji
Abstract:
Mucus is a self-healing gel that lubricates the moist epithelium and provides protection against viruses by binding to viruses smaller than the gel's mesh size and removing them from the mucosal surface by active mucus turnover. As the primary nonaqueous components of mucus (≈0.2%–5%, wt/v), mucins are critical to this function because the dense arrangement of mucin glycans allows multivalence of binding. Following nature's example, bovine submaxillary mucins (BSMs) are assembled into “mucus-lik...     »
Stichworte:
HIV-1; HSV-2; immune suppression; lubricant; mucin hydrogels; self-healing; strain-weakening
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Advanced Science
Jahr:
2022
Band / Volume:
9
Heft / Issue:
32
Seitenangaben Beitrag:
2203898
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1002/advs.202203898
WWW:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202203898
Verlag / Institution:
Wiley
E-ISSN:
2198-38442198-3844
Publikationsdatum:
14.09.2022
TUM Einrichtung:
Fachgebiet für Biomechanik, MW
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