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Titel:

Emulsions of hydrolyzable oils for the zero-order release of hydrophobic drugs

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Tebcharani, Laura; Wanzke, Caren; Lutz, Theresa M.; Rodon-Fores, Jennifer; Lieleg, Oliver; Boekhoven, Job
Abstract:
Drug delivery systems that release hydrophobic drugs with zero-order kinetics remain rare and are often complicated to use. In this work, we present a gellified emulsion (emulgel) that comprises oil droplets of a hydrolyzable oil entrapped in a hydrogel. In the oil, we incorporate various hydrophobic drugs and, because the oil hydrolyzes with zero-order kinetics, the release of the drugs is also linear. We tune the release period from three hours to 50 h by varying the initial oil concentration....     »
Stichworte:
Zero-order drug delivery, Sustained-release, Hydrogel Emulgel Emulsion Hydrophobic drug
Zeitschriftentitel:
Journal of Controlled Release
Jahr:
2021
Band / Volume:
339
Seitenangaben Beitrag:
498-505
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1016/j.jconrel.2021.10.014
WWW:
https://www.sciencedirect.com/science/article/abs/pii/S0168365921005435
Verlag / Institution:
Elsevier BV
E-ISSN:
0168-3659
Publikationsdatum:
01.11.2021
TUM Einrichtung:
Fachgebiet für Biomechanik, MW
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