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Title:

Structural Alterations of Mucins Are Associated with Losses in Functionality

Document type:
Zeitschriftenaufsatz
Author(s):
Marczynski, Matthias; Jiang, Kun; Blakeley, Matthew; Srivastava, Vaibhav; Vilaplana, Francisco; Crouzier, Thomas; Lieleg, Oliver
Abstract:
Commercial mucin glycoproteins are routinely used as a model to investigate the broad range of important functions mucins fulfill in our bodies, including lubrication, protection against hostile germs, and the accommodation of a healthy microbiome. Moreover, purified mucins are increasingly selected as building blocks for multifunctional materials, i.e., as components of hydrogels or coatings. By performing a detailed side-by-side comparison of commercially available and lab-purified variants of...     »
Keywords:
Purification; Building blockes; Macroscopic levels; Medical products; Multi-functional materials; Porcine gastric mucins; Structural alterations; Structural feature; Structural motifs; Glycoproteins
Dewey Decimal Classification:
500 Naturwissenschaften
Journal title:
Biomacromolecules
Year:
2021
Journal volume:
22
Journal issue:
4
Pages contribution:
1600-1613
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1021/acs.biomac.1c00073
WWW:
https://www.scopus.com/record/display.uri?eid=2-s2.0-85104209432&origin=resultslist&sort=plf-f&src=s&st1=Lieleg&st2=Oliver&nlo=1&nlr=20&nls=count-f&sid=5d74543a2ec2798c9fe15407ca5d295d&sot=anl&sdt=aut&sl=35&s=AU-ID("Lieleg,+Oliver"+22835524400)&relpos=3&citeCnt=2
Publisher:
American Chemical Society (ACS)
E-ISSN:
1525-77971526-4602
Date of publication:
22.03.2021
TUM Institution:
Professur für Biomechanik
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