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Titel:

A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology.

Dokumenttyp:
Article; Journal Article
Autor(en):
Müller, Thomas R; Schuler, Corinna; Hammel, Monika; Köhler, Amelie; Jutz, Sabrina; Leitner, Judith; Schober, Kilian; Busch, Dirk H; Steinberger, Peter
Abstract:
Objective: Transgenic re-expression enables unbiased investigation of T-cell receptor (TCR)-intrinsic characteristics detached from its original cellular context. Recent advancements in TCR repertoire sequencing and development of protocols for direct cloning of full TCRαβ constructs now facilitate large-scale transgenic TCR re-expression. Together, this offers unprecedented opportunities for the screening of TCRs for basic research as well as clinical use. However, the functional characterisati...     »
Zeitschriftentitel:
Clin Transl Immunology
Jahr:
2020
Band / Volume:
9
Heft / Issue:
11
Volltext / DOI:
doi:10.1002/cti2.1216
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33251011
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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