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Title:

Metavinculin modulates force transduction in cell adhesion sites.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kanoldt, Verena; Kluger, Carleen; Barz, Christiane; Schweizer, Anna-Lena; Ramanujam, Deepak; Windgasse, Lukas; Engelhardt, Stefan; Chrostek-Grashoff, Anna; Grashoff, Carsten
Abstract:
Vinculin is a ubiquitously expressed protein, crucial for the regulation of force transduction in cells. Muscle cells express a vinculin splice-isoform called metavinculin, which has been associated with cardiomyopathies. However, the molecular function of metavinculin has remained unclear and its role for heart muscle disorders undefined. Here, we have employed a set of piconewton-sensitive tension sensors to probe metavinculin mechanics in cells. Our experiments reveal that metavinculin bears...     »
Journal title abbreviation:
Nat Commun
Year:
2020
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-020-20125-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33335089
Print-ISSN:
2041-1723
TUM Institution:
Institut für Pharmakologie und Toxikologie
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