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Titel:

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy.

Dokumenttyp:
Journal Article
Autor(en):
Viereck, Janika; Bührke, Anne; Foinquinos, Ariana; Chatterjee, Shambhabi; Kleeberger, Jan A; Xiao, Ke; Janssen-Peters, Heike; Batkai, Sandor; Ramanujam, Deepak; Kraft, Theresia; Cebotari, Serghei; Gueler, Faikah; Beyer, Andreas M; Schmitz, Jessica; Bräsen, Jan H; Schmitto, Jan D; Gyöngyösi, Mariann; Löser, Alexandra; Hirt, Marc N; Eschenhagen, Thomas; Engelhardt, Stefan; Bär, Christian; Thum, Thomas
Abstract:
AIMS: Pathological cardiac remodelling and subsequent heart failure represents an unmet clinical need. Long non-coding RNAs (lncRNAs) are emerging as crucial molecular orchestrators of disease processes, including that of heart diseases. Here, we report on the powerful therapeutic potential of the conserved lncRNA H19 in the treatment of pathological cardiac hypertrophy. METHOD AND RESULTS: Pressure overload-induced left ventricular cardiac remodelling revealed an up-regulation of H19 in the ear...     »
Zeitschriftentitel:
Eur Heart J
Jahr:
2020
Band / Volume:
41
Heft / Issue:
36
Seitenangaben Beitrag:
3462-3474
Volltext / DOI:
doi:10.1093/eurheartj/ehaa519
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32657324
Print-ISSN:
0195-668X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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