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Titel:

Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study.

Dokumenttyp:
Journal Article
Autor(en):
Stenzinger, Albrecht; Endris, Volker; Budczies, Jan; Merkelbach-Bruse, Sabine; Kazdal, Daniel; Dietmaier, Wolfgang; Pfarr, Nicole; Siebolts, Udo; Hummel, Michael; Herold, Sylvia; Andreas, Johanna; Zoche, Martin; Tögel, Lars; Rempel, Eugen; Maas, Jörg; Merino, Diana; Stewart, Mark; Zaoui, Karim; Schlesner, Matthias; Glimm, Hanno; Fröhling, Stefan; Allen, Jeff; Horst, David; Baretton, Gustavo; Wickenhauser, Claudia; Tiemann, Markus; Evert, Matthias; Moch, Holger; Kirchner, Thomas; Büttner, Reinhar...     »
Abstract:
INTRODUCTION: Tumor mutational burden (TMB) is a quantitative assessment of the number of somatic mutations within a tumor genome. Immunotherapy benefit has been associated with TMB assessed by whole-exome sequencing (wesTMB) and gene panel sequencing (psTMB). The initiatives of Quality in Pathology (QuIP) and Friends of Cancer Research have jointly addressed the need for harmonization among TMB testing options in tissues. This QuIP study identifies critical sources of variation in psTMB assessm...     »
Zeitschriftentitel:
J Thorac Oncol
Jahr:
2020
Band / Volume:
15
Heft / Issue:
7
Seitenangaben Beitrag:
1177-1189
Volltext / DOI:
doi:10.1016/j.jtho.2020.01.023
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32119917
Print-ISSN:
1556-0864
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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