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Title:

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.

Document type:
Journal Article
Author(s):
Coassin, Stefan; Hermann-Kleiter, Natascha; Haun, Margot; Wahl, Simone; Wilson, Rory; Paulweber, Bernhard; Kunze, Sonja; Meitinger, Thomas; Strauch, Konstantin; Peters, Annette; Waldenberger, Melanie; Kronenberg, Florian; Lamina, Claudia
Abstract:
Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has not been addressed yet. Therefore, we conducted an epigenome-wide analysis of DNA methylation on Lp(a) levels in two population-based studies (total n = 2208). We identified a CpG site in the LPA promoter which was significantly associated with Lp(a)...     »
Journal title abbreviation:
PLoS ONE
Year:
2020
Journal volume:
15
Journal issue:
4
Fulltext / DOI:
doi:10.1371/journal.pone.0232073
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32343731
Print-ISSN:
1932-6203
TUM Institution:
656; 658; Institut für Humangenetik
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