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Titel:

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Autor(en):
Trembinski, D Julia; Bink, Diewertje I; Theodorou, Kosta; Sommer, Janina; Fischer, Ariane; van Bergen, Anke; Kuo, Chao-Chung; Costa, Ivan G; Schürmann, Christoph; Leisegang, Matthias S; Brandes, Ralf P; Alekseeva, Tijna; Brill, Boris; Wietelmann, Astrid; Johnson, Christopher N; Spring-Connell, Alexander; Kaulich, Manuel; Werfel, Stanislas; Engelhardt, Stefan; Hirt, Marc N; Yorgan, Kaja; Eschenhagen, Thomas; Kirchhof, Luisa; Hofmann, Patrick; Jaé, Nicolas; Wittig, Ilka; Hamdani, Nazha; Bischof, C...     »
Abstract:
Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregul...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2020
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-020-15995-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32341350
Print-ISSN:
2041-1723
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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