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Title:

Radiation therapy before radical cystectomy combined with immunotherapy in locally advanced bladder cancer - study protocol of a prospective, single arm, multicenter phase II trial (RACE IT).

Document type:
Article; Clinical Trial, Phase II; Journal Article; Multicenter Study
Author(s):
Schmid, Sebastian C; Koll, Florestan J; Rödel, Claus; Maisch, Philipp; Sauter, Andreas; Beckert, Franziska; Seitz, Anna; Kübler, Hubert; Flentje, Michael; Chun, Felix; Combs, Stephanie E; Schiller, Kilian; Gschwend, Jürgen E; Retz, Margitta
Abstract:
BACKGROUND: Patients with locally advanced bladder cancer (cT3/4 cN0/N+ cM0) have a poor prognosis despite radical surgical therapy and perioperative chemotherapy. Preliminary data suggest that the combination of radiation and immunotherapy does not lead to excess toxicity and may have synergistic (abscopal) anti-tumor effects. We hypothesize that the combined preoperative application of the PD-1 checkpoint-inhibitor Nivolumab with concomitant radiation therapy of the bladder and pelvic region f...     »
Journal title abbreviation:
BMC Cancer
Year:
2020
Journal volume:
20
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s12885-019-6503-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31900121
TUM Institution:
Institut für Diagnostische und Interventionelle Radiologie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Urologische Klinik und Poliklinik
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