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- Original title:
- NMR structural studies of full-length Bcl-xL in nanodiscs
- Translated title:
- NMR-struktrulle Studien von volllängen Bcl-xL in nanodiscs
- Author:
- Raltchev, Kolio Pavlinov
- Year:
- 2020
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Hagn, Franz (Prof. Dr.)
- Referee:
- Hagn, Franz (Prof. Dr.); Reif, Bernd (Prof. Dr.)
- Language:
- en
- Subject group:
- CHE Chemie
- Keywords:
- Bcl-xL, Nanodiscs, tail-anchored proteins, NMR
- Translated keywords:
- Bcl-xL, Nanodiscs, tail-anchored proteins, NMR
- TUM classification:
- CHE 887d
- Abstract:
- The focus of this study is the development of new methods for the production of the full-length tail-anchored membrane proteins, specifically the B-cell lymphoma-extralarge (Bcl-xL), a member of the Bcl-2 family,as well as their structural investigation in phospholipid nanodiscs. The developed methods are applied to studying the membrane-bound and inserted Bcl-xL and to probe its membrane location and possible membrane insertion processes in a native-like environment.
- Translated abstract:
- Der Fokus dieser Arbeit ist die Entwicklung neuer Methoden zur Produktion von tail-anchored Proteinen, insbesondere von Bcl-xL (B-cell lymphoma extra large), sowie deren strukturelle Untersuchung in Phospholipid Nanodiscs. Die entwickelten Methoden werden angewendet, um die membrangebundene und verankerte Form von Bcl-xL zu untersuchen und um deren Membranlokalisation beziehungsweise mögliche Membraninsertionsprozesse in einer möglichst nativen Umgebung zu erforschen.
- WWW:
- https://mediatum.ub.tum.de/?id=1524383
- Date of submission:
- 26.11.2019
- Oral examination:
- 10.02.2020
- File size:
- 9252596 bytes
- Pages:
- 208
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20200210-1524383-1-2
- Last change:
- 09.06.2020
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