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Titel:

A counting-strategy together with a spatial structured model describes RNA polymerase and ribosome availability in Escherichia coli

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Andreas Kremling:
Abstract:
The allocation of resources during bacterial growth is strongly related to the availability of ribosomes and RNA polymerase molecules. Here, coarse-grained models offer a promising start due to their simple structure and the limited number of kinetic parameters. Based on published data sets for proteome and mRNA data in Escherichia coli, and together with mass balance equations describing gene expression, we are able to calculate the number of active molecules (that is, the number of ribosomes t...     »
Stichworte:
Counting strategy; Resource allocation Ribosome and RNA polymerase availability Spatial structured model
Zeitschriftentitel:
Elsevier
Jahr:
2021
Jahr / Monat:
2021-09
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1016/j.ymben.2021.06.006
WWW:
https://www.sciencedirect.com/science/article/abs/pii/S1096717621001051
Eingabe:
06.09.2021
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