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Title:

First In-Human Medical Imaging with a PASylated 89Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer.

Document type:
Journal Article
Author(s):
Richter, Antonia; Knorr, Karina; Schlapschy, Martin; Robu, Stephanie; Morath, Volker; Mendler, Claudia; Yen, Hsi-Yu; Steiger, Katja; Kiechle, Marion; Weber, Wolfgang; Skerra, Arne; Schwaiger, Markus
Abstract:
Purpose: PASylation® offers the ability to systematically tune and optimize the pharmacokinetics of protein tracers for molecular imaging. Here we report the first clinical translation of a PASylated Fab fragment (89Zr∙Df-HER2-Fab-PAS200) for the molecular imaging of tumor-related HER2 expression. Methods: A patient with HER2-positive metastatic breast cancer received 37 MBq of 89Zr∙Df-HER2-Fab-PAS200 at a total mass dose of 70 μg. PET/CT was carried out 6, 24, and 45 h after injection, followed...     »
Journal title abbreviation:
Nucl Med Mol Imaging
Year:
2020
Journal volume:
54
Journal issue:
2
Pages contribution:
114-119
Fulltext / DOI:
doi:10.1007/s13139-020-00638-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32377263
Print-ISSN:
1869-3474
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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