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Titel:

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Dokumenttyp:
Journal Article
Autor(en):
Wang, Lifeng; Sinnott-Armstrong, Nasa; Wagschal, Alexandre; Wark, Abigail R; Camporez, Joao-Paulo; Perry, Rachel J; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T; Soukas, Alexander; Avruch, Joseph; Fried, Susan K; Hauner, Hans; Sadreyev, Rusl...     »
Abstract:
Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also associated with obesity and type 2 diabetes in humans, raising the possibility that additional genetic elements in the locus may have contributed to evolutionary adaptation to famine by promoting energy storage, but which now confer susceptibility to metabolic diseases. We sho...     »
Zeitschriftentitel:
Cell
Jahr:
2020
Band / Volume:
183
Heft / Issue:
3
Seitenangaben Beitrag:
684-701.e14
Volltext / DOI:
doi:10.1016/j.cell.2020.09.017
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33058756
Print-ISSN:
0092-8674
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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