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Title:

Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens.

Document type:
Article; Journal Article
Author(s):
Schulz, Oliver; Hanč, Pavel; Böttcher, Jan P; Hoogeboom, Robbert; Diebold, Sandra S; Tolar, Pavel; Reis E Sousa, Caetano
Abstract:
Conventional type 1 DCs (cDC1s) excel at cross-presentation of dead cell-associated antigens partly because they express DNGR-1, a receptor that recognizes exposed actin filaments on dead cells. In vitro polymerized F-actin can be used as a synthetic ligand for DNGR-1. However, cellular F-actin is decorated with actin-binding proteins, which could affect DNGR-1 recognition. Here, we demonstrate that myosin II, an F-actin-associated motor protein, greatly potentiates the binding of DNGR-1 to F-ac...     »
Journal title abbreviation:
Cell Rep
Year:
2018
Journal volume:
24
Journal issue:
2
Pages contribution:
419-428
Fulltext / DOI:
doi:10.1016/j.celrep.2018.06.038
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29996102
Print-ISSN:
2211-1247
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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