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Title:

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Böttcher, Jan P; Bonavita, Eduardo; Chakravarty, Probir; Blees, Hanna; Cabeza-Cabrerizo, Mar; Sammicheli, Stefano; Rogers, Neil C; Sahai, Erik; Zelenay, Santiago; Reis E Sousa, Caetano
Abstract:
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy. Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produce the cDC1 chemoattractants CCL5 and XCL1. Similarly, in human cancers, intratumoral CCL5, XCL1, and XCL2 transcripts closely correlate with gene signatures of both NK cells and cDC1 and are associate...     »
Journal title abbreviation:
Cell
Year:
2018
Journal volume:
172
Journal issue:
5
Pages contribution:
1022-1037.e14
Fulltext / DOI:
doi:10.1016/j.cell.2018.01.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29429633
Print-ISSN:
0092-8674
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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