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Titel:

Biological and clinical insights from genetics of insomnia symptoms.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Lane, Jacqueline M; Jones, Samuel E; Dashti, Hassan S; Wood, Andrew R; Aragam, Krishna G; van Hees, Vincent T; Strand, Linn B; Winsvold, Bendik S; Wang, Heming; Bowden, Jack; Song, Yanwei; Patel, Krunal; Anderson, Simon G; Beaumont, Robin N; Bechtold, David A; Cade, Brian E; Haas, Mary; Kathiresan, Sekar; Little, Max A; Luik, Annemarie I; Loudon, Andrew S; Purcell, Shaun; Richmond, Rebecca C; Scheer, Frank A J L; Schormair, Barbara; Tyrrell, Jessica; Winkelman, John W; Winkelmann, Juliane; Hveem...     »
Abstract:
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2019
Band / Volume:
51
Heft / Issue:
3
Seitenangaben Beitrag:
387-393
Volltext / DOI:
doi:10.1038/s41588-019-0361-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30804566
Print-ISSN:
1061-4036
TUM Einrichtung:
Lehrstuhl für Neurogenetik (Prof. Winkelmann); Neurologische Klinik und Poliklinik
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