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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lukowski, R; Weinmeister, P; Bernhard, D; Feil, S; Gotthardt, M; Herz, J; Massberg, S; Zernecke, A; Weber, C; Hofmann, F; Feil, R
Title:
Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.
Abstract:
Nitric oxide (NO) is of crucial importance for smooth muscle cell (SMC) function and exerts numerous, and sometimes opposing, effects on vascular restenosis. Although cGMP-dependent protein kinase type I (cGKI) is a principal effector of NO, the molecular pathway of vascular NO signaling in restenosis is unclear. The purpose of this study was to examine the functional role of the smooth muscle cGMP/cGKI signaling cascade in restenosis of vessels.Tissue-specific mouse mutants were generated in wh...    »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2008
Journal volume:
28
Journal issue:
7
Pages contribution:
1244-50
Language:
eng
Print-ISSN:
1079-5642
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Pharmakologie und Toxikologie
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