Benutzer: Gast  Login
Titel:

Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Kawasaki, Y; Kugimiya, F; Chikuda, H; Kamekura, S; Ikeda, T; Kawamura, N; Saito, T; Shinoda, Y; Higashikawa, A; Yano, F; Ogasawara, T; Ogata, N; Hoshi, K; Hofmann, F; Woodgett, JR; Nakamura, K; Chung, UI; Kawaguchi, H
Abstract:
cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. Using radiographic analysis, we determined that this growth defect was a consequence of an elongated growth plate and impaired chondrocyte hypertrophy. To investigate the mechanism of cGKII-mediated chondrocyte hypertrophy, we performed a kinase substrate array and identified glycogen synthase kinase-3beta (GSK-3...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2008
Band / Volume:
118
Heft / Issue:
7
Seitenangaben Beitrag:
2506-15
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI35243
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18551195
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
 BibTeX