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Title:

Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Sakowicz-Burkiewicz, M; Nishanth, G; Helmuth, U; Drögemüller, K; Busch, DH; Utermöhlen, O; Naumann, M; Deckert, M; Schlüter, D
Abstract:
Protein kinase C-theta (PKC-theta) is essential for the activation of T cells in autoimmune disorders, but not in viral infections. To study the role of PKC-theta in bacterial infections, PKC-theta(-/-) and wild-type mice were infected with Listeria monocytogenes (LM). In primary and secondary listeriosis, the numbers of LM-specific CD8 and CD4 T cells were drastically reduced in PKC-theta(-/-) mice, resulting in increased CFUs in spleen and liver of both PKC-theta(-/-) C57BL/6 and BALB/c mice....     »
Journal title abbreviation:
J Immunol
Year:
2008
Journal volume:
180
Journal issue:
8
Pages contribution:
5601-12
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18390745
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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