PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.

Schormair, B; Kemlink, D; Roeske, D; Eckstein, G; Xiong, L; Lichtner, P; Ripke, S; Trenkwalder, C; Zimprich, A; Stiasny-Kolster, K; Oertel, W; Bachmann, CG; Paulus, W; Högl, B; Frauscher, B; Gschliesser, V; Poewe, W; Peglau, I; Vodicka, P; Vávrová, J; Sonka, K; Nevsimalova, S; Montplaisir, J; Turecki, G; Rouleau, G; Gieger, C; Illig, T; Wichmann, HE; Holsboer, F; Müller-Myhsok, B; Meitinger, T; Winkelmann, J

doi:10.1038/ng.190

Benutzer: Gast

Institut für Humangenetik

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Titel:: PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Schormair, B; Kemlink, D; Roeske, D; Eckstein, G; Xiong, L; Lichtner, P; Ripke, S; Trenkwalder, C; Zimprich, A; Stiasny-Kolster, K; Oertel, W; Bachmann, CG; Paulus, W; Högl, B; Frauscher, B; Gschliesser, V; Poewe, W; Peglau, I; Vodicka, P; Vávrová, J; Sonka, K; Nevsimalova, S; Montplaisir, J; Turecki, G; Rouleau, G; Gieger, C; Illig, T; Wichmann, HE; Holsboer, F; Müller-Myhsok, B; Meitinger, T; Winkelmann, J
Abstract:: We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, P(nominal/lambda corrected) = 5.91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS. «
We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, P(nominal/lambda corrected) = 5.91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the... »
Zeitschriftentitel:: Nat Genet
Jahr:: 2008
Band / Volume:: 40
Heft / Issue:: 8
Seitenangaben Beitrag:: 946-8
Sprache:: eng
Volltext / DOI:: doi:10.1038/ng.190
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/18660810
Print-ISSN:: 1061-4036
TUM Einrichtung:: Institut für Humangenetik; Neurologische Klinik und Poliklinik
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