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Title:

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.

Document type:
Journal Article; Article
Author(s):
Yfanti, C; Mengele, K; Gkazepis, A; Weirich, G; Giersig, C; Kuo, WL; Tang, WJ; Rosner, M; Schmitt, M
Abstract:
Insulin-degrading enzyme (IDE, insulysin, insulinase; EC 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. Recently, protein expression of IDE has been demonstrated in the epithelial ducts of normal breast and breast cancer tissue. Utilizing four different antibodies generated against different epitopes of the IDE molecule, we performed Western blot analysis and immunohistochemical...     »
Journal title abbreviation:
Int J Mol Med
Year:
2008
Journal volume:
22
Journal issue:
4
Pages contribution:
421-31
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18813847
Print-ISSN:
1107-3756
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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