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Title:

No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts.

Document type:
Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Article
Author(s):
Büning, C; Schmidt, HH; Molnár, T; Drenth, JP; Fiedler, T; Gentz, E; Todorov, T; Baumgart, DC; Sturm, A; Nagy, F; Lonovics, J; de Jong, DJ; Landt, O; Kage, A; Nickel, R; Buttner, J; Lochs, H; Witt, H
Abstract:
BACKGROUND: A recent study reported that the c.30T>A (p.Cys10Ter; rs2043211) variant, in the CARD8 (TUCAN) gene, is associated with Crohn's disease (CD). The aim of this study was to analyze the frequency of p.C10X in 3 independent European (IBD) cohorts from Germany, Hungary, and the Netherlands. METHODS: We included a European IBD cohort of 921 patients and compared the p.C10X genotype frequency to 832 healthy controls. The 3 study populations analyzed were: (1) Germany [CD, n = 317; ulcerat...     »
Journal title abbreviation:
Inflamm Bowel Dis
Year:
2008
Journal volume:
14
Journal issue:
3
Pages contribution:
332-7
Language:
eng
Fulltext / DOI:
doi:10.1002/ibd.20337
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18092344
Print-ISSN:
1078-0998
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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