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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Siegmund, K; Rückert, B; Ouaked, N; Burgler, S; Speiser, A; Akdis, CA; Schmidt-Weber, CB 
Title:
Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells. 
Abstract:
Forkhead box p3 (FOXP3) is known to program the acquisition of suppressive capacities in CD4(+) regulatory T cells (Treg), whereas its role in CD8(+) T cells is unknown. The current study investigates whether FOXP3 also acts as a Treg master switch in peripheral blood and tonsillar CD8(+) T cells. Single-cell analyses reveal the existence of a FOXP3(+)CD8(+) population in human tonsils, whereas FOXP3(+)CD8(+) T cells are rarely detected in peripheral blood. Tonsillar FOXP3(+)CD8(+) T cells exhib...    »
 
Journal title abbreviation:
J Immunol 
Year:
2009 
Journal volume:
182 
Journal issue:
Pages contribution:
2124-30 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)